Overview

5-Amino-1MQ is a membrane-permeable quinolinium derivative described in the scientific literature as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT catalyses the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH).

In the laboratory it is used as a tool compound to modulate NNMT activity in enzyme assays and cultured-cell models. No claims are made regarding effects in humans or animals.

Typical in-vitro applications

• NNMT enzyme-inhibition and kinetics assays
• NAD⁺ salvage-pathway and nicotinamide-metabolism studies in cell culture
• SAM / SAH methylation-flux experiments
• Reference standard for HPLC and LC-MS method development

Compound data

• Compound: 5-Amino-1MQ (5-amino-1-methylquinolinium)
• Compound class: Small-molecule quinolinium compound
• Target enzyme: Nicotinamide N-methyltransferase (NNMT)
• Net content: 50 mg per vial (stated for analytical and preparative calculations)
• Purity specification: ≥99% (HPLC); measured value on the lot certificate of analysis
• Form: Solid powder
• Intended use: In-vitro laboratory research only

Storage & handling

• Store the sealed vial at −20 °C, dry and protected from light.
• Allow the vial to reach room temperature before opening to avoid condensation.
• Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).
• Shipped at ambient temperature in insulated, tamper-evident packaging.

Analytical documentation

HPLC purity and LC-MS identity are tested for every lot. Certificates of analysis and third-party test reports are published in our COA library on the About Us page.

For laboratory research use only. Not for human or veterinary use. See our Research Use Disclaimer.